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KMID : 0618720050110010058
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Journal of The Korea Institute of Oriental Medicine Informatics
2005 Volume.11 No. 1 p.58 ~ p.73
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Effects of Kagammokbanggi-Tang on the Adjuvant-Induced Arthritis in Rats
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Hwang Duk-Soon
Kim Soon-Joong
Seo Il-Bok
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Abstract
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Objectives: This study was to investigate the effect of Kagammokbanggi-tang on the Freund’s Complete Adjuvant(FCA)-induced arthritis in rats.
Methods: Arthritis was induced by intradermal injection of FCA into base of tail. Arthritic rats were divided into control(n=10) and sample(n=10) group. Control group was taken normal saline for twenty days and sample group was taken extracts of Kagammokbanggi-tang for same duration. Normal group(n=10), non-arthritic group, was injected with mineral oil and was taken normal saline for twenty days. Body weight, paw edema volume and ankle joint thickness were measured at 0, 10, 15, 20 days after treatment. TNF-α, IL-1β, IL-6, PGE₂in synovia were analysed by ELISA at 20 days after treatment. Histochemical investigation of NADPH-d in the PAG and histopathological study on the ankle joint were performed at 20 days after treatment.
Results: Paw edema volume, ankle joint thickness, TNF-α, IL-1β, IL-6, PGE₂, NADPH-d of sample group were significantly decreased compared with control group.
Conclusions: These results indicated that Kagammokbanggi-tang has antiarthritic and analgesic effects, and inhibited expression of NOS on the progression of FCA- induced arthritis in rats.
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KEYWORD
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Kagammokbanggi-tang, Adjuvant arthritis, NOS, NADPH-d
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